The south-western boundary with the Cusco Region is known as the Isthmus of Fitzcarrald, a series of small mountains that separate the Madre de Dios River and the Urubamba River.
The most important rivers are those in the Madre de Dios River watershed:
Due to the vast size of the area and its low population density, rivers provide the best way of getting from one town to another. Human activity is invariably confined to riverbanks. A number of explorers have searched for the lost city of Paititi in the jungle within the region
The only road of note is between the town of Puerto Maldonado and the city of Cuzco (530 km away in Cuzco Region). However, it is in very poor condition and flights between Cuzco and Puerto Maldonado remain the most common and reliable method of transport between the two. From Puerto Maldonado there is a road to the mining town of Laberinto ("Labyrinth") (about 50 km long). A second road is between the village of Atalaya and Cuzco. It is a roughly 300 km long single track road that is impassable in the rainy season.
Gold mining is the only other large industry of the region, confined mainly to the beaches of the Inambari and Madre de Dios Rivers. Contrary to recent propaganda, this presents both a major environmental and public health problem. Most gold miners use liquid mercury to extract gold particles from the river silt. They often handle the toxic liquid mercury with their bare hands. To purify the gold particles, the mercury is burned off. After being vaporized, mercury particles contaminate the surrounding ecosystems. Mercury bioaccumulates throughout the food chain to become concentrated in top predators such as large river fish and carnivorous birds. Exposure to or the ingestion of mercury have been shown to result in a variety of neurological and congenital health problems.
Other serious environmental problems in the region include loss of forest cover for agriculture, illegal selective logging (particularly for mahogany) and illegal poaching of endangered species (particularly the Giant River Otter, Amazonian turtles, caimans, and monkeys and macaws as pets).
The national bird of Peru, the Andean Cock-of-the-rock, is also found in Madre de Dios and suffers from poaching and habitat disturbance.