Macro-Jê (also spelled Macro-Gê) is a medium-sized language stock in South America centered around the Jê language family, first proposed in 1926 and undergoing moderate modifications since then. Kaufman (1990) finds the proposal "probable".

• Jê-Kaingang (16 languages in three branches: Kaingáng [18,000 speakers of four languages], and northern and southern Jê languages such as Xavánte [8000 speakers])
• Krenák (Botocudo)
• Borôro
• Kamakã [extinct]
• Karajá
• Karirí [extinct]
• Maxakalían
• Ofayé (Opaie)
• Purían [extinct]
• Rikbaktsá

Eduardo Ribeiro of the University of Chicago finds no evidence to classify Fulniô (Yatê) or Guató as Macro-Je, pace Kaufman, nor Otí and Chiquitano, pace Greenberg.

These languages share irregular morphology with the Tupi and Carib families, and Rodrigues (2000) and Ribeiro connect them all as a Je-Tupi-Carib family.