It was originally established in 1850 as Roper Hospital and was the first teaching hospital in the state. During the 1886 Charleston earthquake, critical structural damage to the Roper Hospital forced The Medical College of the State of South Carolina to close its doors, leaving Charleston without a teaching hospital.
In 1946 the South Carolina General Assembly passed a $4 million bill to construct a new teaching hospital that was brought under the control of the Medical College of South Carolina. Construction began in 1951 and the Medical College of South Carolina Hospital was completed and dedicated on May 10, 1955 and opened its doors to its first patients on September 26, 1955. It was later renamed Medical University of South Carolina Hospital and has now been officially shortened to simply MUSC Medical Center.
Today, MUSC Medical Center is a world-class teaching hospital with the MUSC Transplant Center ranked as one of the top ten organ transplantation centers in the nation. MUSC Medical Center is a Level I Trauma Center and is the regional referral center for the Lowcountry of South Carolina.