• Motherfucker
• Morning Formation

In music:

• "Mofo" (song) from the Irish band U2's rock/techno album, Pop
• The MOFO Project/Object, an album box set by Frank Zappa
• The Uplift Mofo Party Plan, an album by the Red Hot Chili Peppers, a U.S. rock band

In arts and entertainment:

• "Mofo the Psychic Gorilla" from Penn & Teller's comic illusion stage acts

• Mofo; Morrison Follower, Fans of the WWE wrestler John Morrison (John Hennigan)

In technology:

• Mozilla Foundation, a non-profit organization that exists to support and provide leadership for the open source Mozilla project

In law:

• Morrison & Foerster, a large law firm based in San Francisco, California