The show pitted several young vocalists from various Latin-American countries against each other. They were sealed inside a studio living quarters and filmed 24 hours a day. An edited version of their daily activities was broadcast each night. They spent their days attending various performance classes, and every Wednesday performed a song in the weekly prueba de talento. The loser of the prueba was a candidate for dismissal from the household, and the contestants voted to select a second candidate. The public was then asked to choose one of the two candidates to be sent home from the studio. Fourteen original protagonistas were thus whittled down to four finalistas. The winners were the Cuban Barbara Higuera and the Dominican Miguel Angel Guzman. The show was immensely popular among young Latinos, but controversial among the older audience. The show was hosted by Puerto Rican singer Carlos Ponce.
There is also a Chilean version of the show, aired in Canal 13, where the winner was Ximena Abarca. The main song was performed by Catalina Bono, winner of Protagonistas de la Fama, local version of Protagonistas de Novela.