He is from Príncipe and has held a number of high positions on the island, most notably president of the Pagué district assembly and president of the Príncipe regional government from 29 April 1995 to 12 April2002.
Damião Vaz d'Almeida's government consisted of ministers from both the MLSTP-PSD and Independent Democratic Action (ADI) parties.
He presented his resignation to President Menezes on 2 June 2005, saying his working relationship with Menezes had deteriorated to the point where they could no longer work together. The two disagreed about how to handle a civil servants' strike and about Menezes's awarding of offshore oil blocks. Six days after his resignation, a new government led by Maria do Carmo Silveira was sworn in.