He has had a gap in his teeth ever since birth. When asked if he has tried to get it out he says, "My gap is my trademark; without my gap, I am just an annoying game show host."
He is number 92 on Comedy Central's list of the 100 greatest standups of all time. Anderson was also in the movie Coming to America. According to Maxim, he was listed as the 11th worst comedian of all time. However, at the same time, Anderson was 5th on Maxim's list of the "worst comics of all time."
Anderson created and produced a Saturday morning series for FOX called Life with Louie in 1995. The series was based on the childhood of Louie Anderson, growing up with 10 siblings, a sweet-hearted mother and a loud, war crazed father. It also detailed how he was picked on when he was younger due to his weight, and how he used comedy as a way to deal with the teasing. The show was a 3-year hit on FOX. It also won two Emmy Awards.
In 1996, he tried once again to be part of a television sitcom when he created and starred in The Louie Show for CBS. The show had Anderson playing a psychotherapist living in Duluth, Minnesota. The show only lasted six episodes before it was canceled. Anderson later said he was dissatisfied and disappointed with the series, claiming that CBS changed it so much that by the end it wasn't even his show anymore.
Anderson was let go from the show in 2002 and replaced by former Home Improvement star Richard Karn. Somewhat bitter over losing the job, Anderson claimed, on the Family Feud E! True Hollywood Story, that the show wouldn't last more than one season without him. As of 2008, the show remains on the air, although Richard Karn was replaced by John O'Hurley in 2006 after four seasons.
Anderson put together a special 9/11 tournament between the New York Fire Department (FDNY) and the New York Police Department (NYPD), with Anderson putting up $75,000 of his own funds toward both organizations in helping the recovery of the September 11, 2001 attacks.
He has starred in his own comedy specials on Home Box Office and Showtime and frequently appears on late night talk shows. He has made appearances on network television in Scrubs, Grace Under Fire, Touched by an Angel and Chicago Hope. He recently guest starred on the Adult Swim cameo-filled show Tom Goes to the Mayor.
He has worked with numerous charities. Shortly after 9/11, Louie came up with an idea to do a show in New York City for the NYPD and FDNY Widows Fund. He is also the co-founder of the H.E.R.O. organization whose mission is to empower people who are homeless or at risk of being homeless to "attain maximum self-sufficiency." H.E.R.O. works with a variety of local agencies to enroll clients in empowerment training, that will allow them to set goals for themselves and create action plans to accomplish these goals.
Anderson played in the 2006 World Series of Poker Main Event in Las Vegas. He was eliminated on the first day of play, during which he received a 10-minute penalty that the tournament director could impose on people caught using foul language at the poker tables.
Anderson initially paid Gordon $100,000 in hush money, fearing the story would threaten his starring roles in two family-oriented series, but when Gordon's demands increased to $250,000 in 2000, he informed law enforcement authorities. Gordon was arrested and sentenced to 21 months in prison, a $4,000 fine, and 3 years probation.