It is commonly prescribed for major depressive disorder, anxiety, insomnia, neuropathic/chronic pain, and treatment resistant depression.
Before dispensing medication on a set course, the first prescribed dosage to a patient must be 70mg (one tablet) to be taken at NIGHT only. If no adverse side effects have been reported then the next course would be 140mg (2 tablets to be taken at NIGHT) for a period of 2-3 weeks.
Then again, if no adverse side effects have been reported, the patient must undergo the full dosage of 210mg per DAY for a period of 3 WEEKS.
If the patient is using the maximum daily dosage of 210mg, then the dosage must be divided into THREE SEPARATE time slots, preferably one in the morning, one in the afternoon and one at night; or alternatively one in the morning and two at night (it is safe to take two 70mg tablets at the same time).
G.B. patent 1,177,525 filed on 1967-04-13 by the Swedish Leo corporation (Leo Aktiebolaget) covers Lofepramine as a member of a family of heterocyclic aminoketones, touting as a primary object low toxicity of oral dosage in mice relative to imipramine, amitriptyline, and desipramine for comparable effectiveness.
U.S. patent 3,637,660 granted on 1972-01-25 covers Lofepramine as a member of a family of dibenzazepine derivatives, with similar description and claims.
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