Initially, Locomotion was dedicated to classic animation, airing a mix of King Features animation titles like Phantom 2040, Popeye, and The Legend of Prince Valiant, shows like Galaxy Rangers, Felix the Cat, Lupin III. By 2000, they began airing more alternative and adult-oriented animation from the US, the United Kingdom, and Latin America. As the network grew, most of their programming consisted of Japanese animation titles from the likes of ADV Films, Bandai, and others as well as adult shows like South Park, The Critic, Crapston Villas and Duckman.
Locomotion was also dedicated to showing works of experimental animation from all over the world throughout the day on-air and online. They aired experimental programming featuring video jockeys, artists who worked with video as a medium. Many fans of the programming, particularly fans of anime, felt that these interstitials were unnecessary and pointless to the programming.
One of Locomotion's VJ projects was a computer-rendered character known as "Loco." The character, which mostly appeared during commercial breaks, made humorous comments, and did nonsensical things entertaining the viewers. The mascot disappeared as the channel changed its image.
A final, yet brief reference of "Loco" when Animax replaced Locomotion, which is the part where the special agents sent to save Locomotion, they received a call from "Loco" before he gets killed.
Locomotion was bought by Sony Pictures Entertainment Latin America on January 2005. During the time since the bought of the network and until the shutdown, they start to drop the non-anime shows from their programming and focus on anime shows. The network officially ceased to exist at 11:00 a.m. of July 31 of the same year (however, the broadcast of Locomotion stops on the night of July 30 and was replaced by a countdown clock). From then on, the network has been transformed into the Latin American branch of Animax. Of all the programming broadcast previously in Locomotion, only Saber Marionette J, Saber Marionette J to X, Soul Hunter/Senkai-den Hōshin Engi, Serial Experiments Lain, Candidate for Goddess and Earth Girl Arjuna were picked and broadcast by Animax on their early programming. As of February 2006, all those series were off the air.
The non-anime shows produced by MTV Networks and broadcast on Locomotion (like South Park, The Ren and Stimpy Show and Æon Flux) were picked and shown on a weekend animation block by MTV Latin America, but in November 2006, this block was replaced with Animatosis (a Sic 'Em Friday-alike block) and all the shows (with the exception of South Park) were cancelled. Bob and Margaret is shown (as of January 2006) in the Latin American version of Adult Swim. The Critic is currently broadcast in the Latin American version of HBO Family. Other shows, like Duckman hasn't been show again on Latin America since the Locomotion shutdown.
Locomotion also had an hour block called "Locotomia" where international experimental animations where aired.
Locomotion had a 30 min. block, called Fracto, where they featured music and design experiments that could be considered as experimental animation.
Animax Latin America operates with two feeds: One in Venezuela, which is projected toward Spanish-speaking countries, and one in Brazil, which features its programming with Portuguese dubs for Brazilian audiences. These feeds are currently the only ones in the entire Americas.
The netwotk's initial lineup featured some series that were broadcast previously on Locomotion, including Earth Girl Arjuna, the entire Saber Marionette series, Soul Hunter and Serial Experiments Lain; since then, newer anime series were premiered on the channel, including Gantz, Noir, Twin Spica, Mythical Sleuth Loki, Samurai 7, Hungry Heart: Wild Striker, The Prince of Tennis, Hunter x Hunter, Vandread, Burst Angel, Saikano, Excel Saga and others. About Excel Saga, although its final episode was never aired in Japan due to content reasons, Animax did air it (unedited) across its two Latin American feeds.
Several dubbing studios have participated in the translation of the aforementioned series for their premiere on Animax, and are located in key countries like Mexico, Brazil, Argentina and Venezuela. After Animax's arrival in 2005, numerous series have been translated and dubbed into Spanish and Portuguese languages, including Blood+, The Twelve Kingdoms, Steel Angel Kurumi, Noir, Wolf's Rain, Martian Successor Nadesico, Galaxy Angel and others.