Little Dry Creek is a short tributary of the South Platte River, approximately 6 miles (10 km), in Arapahoe County, Colorado in the United States. The creek drains a suburban area south of Denver. It rises in Centennial, west of Interstate 25, and flows generally northwest into Englewood. It has historically been used for irrigation and feeds an aqueduct that runs parallel to it. The creek no longer reaches South Platte above ground. The former mouth of the creek is located just northwest of the junction of U.S. Highway 85 and U.S. Highway 285, across from the former site of the Cinderella City Mall.

The mouth of the creek is noted as the location of the first significant gold discovery in present-day Colorado. In the first week of July 1858, William Green Russell and his brothers discovered a gold pocket yielded several hundred dollars worth of gold. The discovery set off the Colorado Gold Rush in the following year.