Leukoencephalopathy

The term Leukoencephalopathy is a broad term for leukodystrophy-like diseases (PMID 17414998). It is applied to all brain white matter diseases, whether their molecular cause is known. It can refer specifically to any of these diseases:

• Progressive multifocal leukoencephalopathy
• Toxic leukoencephalopathy
• Leukoencephalopathy with vanishing white matter
• Leukoencephalopathy with neuroaxonal spheroids
• Reversible posterior leukoencephalopathy syndrome
• megalencephalic leukoencephalopathy with subcortical cysts
• hypertensive leukoencephalopathy

It can also refer to MLC1 or Megalencephalic leukoencephalopathy with subcortical cysts 1, a human gene related to the disease of the same name.