It is viewed as being a rival suburb to the neighbouring suburb of Kalamunda directly to the north. The main access to the suburb from the Swan Coastal Plain is via Welshpool Road, that snakes its way up the side of the Darling Scarp from the suburb of Wattle Grove. A secondary road, Crystal Brook Road, also joins up at an intersection at the top part of Welshpool Road, near the Lions Lookout and BP service station. Lesmurdie can also be accessed from Kalamunda, Walliston, Carmel and Bickley, primarily through Canning Road, and through other roads and backstreets.
The main road is Lesmurdie Road, which starts from the south as a T-junction with Welshpool Road and finishes at a roundabout intersection with Canning Road and Lesmurdie Road East. Important secondary roads include Falls Road, Grove Road, Glyde Road, Gladys Road, Sanderson Road and Pomeroy Road. The shopping centres in the area are the Lesmurdie Village on Sanderson Road and the Lesmurdie Road Shopping Centre on the corner of Rooth Rd and Lesmurdie Rd.