A native of Lucca, he arrived in Basel in 1542 and was a disciple of Pietro Martire Vermigli. As a printer he started as an assistant to the renowned Johannes Oporinus and set up a press of his own in 1558. His Italian connections in Padua helped him act as a go between among reformed thinkers and writers, such as Lelio Sozini, Celio Secundo Curione and Theodor Zwinger, his son-in-law.