Lactate-malate transhydrogenase

(S)-lactate + oxaloacetate $rightleftharpoons$ pyruvate + malate

Thus, the two substrates of this enzyme are (S)-lactate and oxaloacetate, whereas its two products are pyruvate and malate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-lactate:oxaloacetate oxidoreductase. This enzyme is also called malate-lactate transhydrogenase. This enzyme participates in pyruvate metabolism. It employs one cofactor, nicotinamide D-ribonucleotide.

References

• Allen SH "The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus". J. Biol. Chem. 241 5266–75.
• Allen SH, Patil JR "Studies on the structure and mechanism of action of the malate-lactate transhydrogenase". J. Biol. Chem. 247 909–16.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes