(S)-3-(imidazol-5-yl)lactate + NAD(P)+ $rightleftharpoons$ 3-(imidazol-5-yl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (S)-3-(imidazol-5-yl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(imidazol-5-yl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase. This enzyme is also called imidazol-5-yl lactate dehydrogenase.

References

• Coote JG, Hassall H "The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans". Biochem. J. 111 237–9.
• Cortese R, Brevet J, Hedegaard J, Roche J "[Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B]". C. R. Seances. Soc. Biol. Fil. 162 390–5.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes