L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.
L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands
present on endothelial
cells will bind to leukocytes expressing L-selectin, which causes the leukocytes to become localised at that point. The receptor is also found on the cell surfaces of "naive" T cells
, which have not yet encountered their specific antigen. This surface expression is lost after the cells are activated.