, a L-dopachrome isomerase
is an enzyme
the chemical reaction
- L-dopachrome 5,6-dihydroxyindole-2-carboxylate
Hence, this enzyme has one substrate, L-dopachrome, and one product, 5,6-dihydroxyindole-2-carboxylate.
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is L-dopachrome keto-enol isomerase. Other names in common use include dopachrome tautomerase, tyrosinase-related protein 2, TRP-1, TRP2, TRP-2, tyrosinase-related protein-2, dopachrome Delta7,Delta2-isomerase, dopachrome Delta-isomerase, dopachrome conversion factor, dopachrome isomerase, dopachrome oxidoreductase, dopachrome-rearranging enzyme, DCF, DCT, dopachrome keto-enol isomerase, and L-dopachrome-methyl ester tautomerase. This enzyme participates in tyrosine metabolism and melanogenesis.
- Jara JR, Lozano JA "Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase". Biochem. J. 313 447–53.
- Pawelek JM "Dopachrome conversion factor functions as an isomerase". Biochem. Biophys. Res. Commun. 166 1328–33.
- Joshua GW, Selkirk ME, Zhang Y, Meyer DJ "Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi". Biochem. J. 335 495–8.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes