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L-3-cyanoalanine synthase

In enzymology, a L-3-cyanoalanine synthase is an enzyme that catalyzes the chemical reaction

L-cysteine + hydrogen cyanide rightleftharpoons L-3-cyanoalanine + hydrogen sulfide

Thus, the two substrates of this enzyme are L-cysteine and hydrogen cyanide, whereas its two products are L-3-cyanoalanine and hydrogen sulfide.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide L-3-cyanoalanine-forming). Other names in common use include beta-cyanoalanine synthase, beta-cyanoalanine synthetase, beta-cyano-L-alanine synthase, and L-cysteine hydrogen-sulfide-lyase (adding HCN). This enzyme participates in cyanoamino acid metabolism.


  • Akopyan TN, Braunstein AE, Goryachenkova EV "Beta-cyanoalanine synthase: purification and characterization". Proc. Natl. Acad. Sci. U. S. A. 72 1617–21.
  • Castric PA, Conn EE "Formation of -cyanoalanine by O-acetylserine sulfhydrylase". J. Bacteriol. 108 132–6.
  • Hendrickson HR "The beta-cyanoalanine synthase of blue lupine". Fed. Proc. 27 593.
  • Hendrickson HR, Conn EE "Cyanide metabolism in higher plants. IV. Purification and properties of the beta-cyanolanine synthase of blue lupine". J. Biol. Chem. 244 2632–40.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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