Kỳ Duyên was born in Saigon, South Vietnam, and was 6 years old during the Fall of Saigon. Her family was anti-communist and worried that they would be persecuted by the North Vietnamese government if it succeeded in defeating South Vietnam. Her father is a former prime minister, vice president, and general, Nguyen Cao Ky.
Kỳ Duyên currently works as a Master of Ceremonies for Thuy Nga's Paris By Night videos and lives in Orange County, California. She is married to Trinh Hoi, a refugee lawyer and concert promoter.
Her father had made arrangements for their political asylum in the United States. She grew up in Fairfax, Virginia, and then the family moved to Huntington Beach, California where she graduated from Marina High School.
She attended California State Polytechnic University and then graduated from Western State University College of Law with high honors.