Knowsley North and Sefton East is a constituency represented in the House of Commons of the Parliament of the United Kingdom. It elects one Member of Parliament (MP) by the first past the post system of election.
The constituency is bordered in the south by Knowsley South; in the west by Crosby; in the north by West Lancashire; in the southwest by Liverpool Walton, Liverpool West Derby, and Bootle and in the east by St Helens North and St Helens South.
Following decisions by the Boundary Commission for England, Knowsley North and Sefton East is to be abolished for the next General Election. This seat will form a small part of a new Knowsley seat, with the Crosby, Maghull and Formby elements moving into a new Sefton Central constituency.