On November 28, 2006, Alexandra Hospital marked the first milestone for its new hospital with a groundbreaking ceremony at the new hospital site. The guest-of-honor was the Health Minister Khaw Boon Wan. An exhibition titled "Metamorphosis: From Old to New" was held at the same time, showcasing photographs depicting the transformation of the existing hospital building in Alexandra Road from pre- and post-independence years to the present times. 3-dimensional models and perspectives of the new hospital building were also on display.
On May 16, 2007, Health Minister Khaw Boon Wan, while attending the HIMSS AsiaPac 2007 conference, announced that the new general hospital in Yishun has been named Khoo Teck Puat Hospital. In acknowledgement of the S$125 million donation made by the late hotelier’s Khoo Teck Puat family towards building and funding of the hospital. The hospital, when ready, will be at the front line of technology. The new hospital would be different from other hospitals as it promises to put patients first and aims to minimise bureaucracy and paperwork.
On September 30, 2007, Health Minister Khaw, at a community event in Yishun, noted that additional land parcels set aside around the Khoo Teck Puat Hospital could be used for construction of further, more specialised health-care facilities. Beyond 2020, this might eventually create a health-care cluster similar to the diverse facilities now in the vicinity of Singapore General Hospital, providing high-quality healthcare services to the growing population in the north. Possible inclusions in the cluster are a community hospital and medical-tourist hotels.
The hospital is to be fully operational by 2012.
The hospital will also incorporate environmentally friendly features. The building will use 50% less energy than other newer hospitals such as Tan Tock Seng Hospital, Changi General Hospital and Kandang Kerbau Women's and Children's Hospital, a savings of more than S$1 million a year on utilities bill.
"Fins" along the building's walls are designed to channel the prevailing north-east winds into the building. Wind tunnel tests conducted at the National University of Singapore found that the "fins" would enhance the air flow by 20 to 30%. There will also be sunshades over the windows to protect patients from the direct glare of sunlight. The shades will also re-direct the light towards the ceiling to enhance the brightness of the wards and save on the use of energy. Large fans in public areas will be powered by solar panels on the roof. The air-conditioning system will draw supply air from its internal courtyards, where the air is cooler, hence reducing the cooling loads.