Wilhoite is an accomplished musician with two widely released albums, Pitch Like a Girl (1997, Daves' Record Company) and Shiva (2000, Ruby Ray Records). Her songs have appeared in such films as Murphy's Law (1986), Valerie Flake (1999), and East of A (2000), as well as on the popular television series Buffy the Vampire Slayer ("Wish We Never Met" from Pitch Like a Girl appeared in the season three episode, "Consequences").
Wilhoite has starred in films such as: Private School (1983), Dream Demon (1987), Road House (1989), Lorenzo's Oil (1992), Color of Night, Fire in the Sky (1993), (1994), The Edge (1997), Drowning Mona (2000) and Pay It Forward (2000). She has guest starred in dozens of television series including Cop Rock, Twin Peaks, Mad About You, Ally McBeal, Family Guy, Quantum Leap, Boomtown, Will & Grace, Charmed, 24, The 4400 and Boston Legal; and has had recurring roles on L.A. Law as Benny Stulwicz's wife, Rosalie Hendrickson Stulwicz, ER as Susan Lewis' sister, Chloe Lewis and Gilmore Girls as Liz Danes, sister of Luke Danes and mother of Jess Mariano.
In May 2006, Wilhoite wrote and performed a one-woman show, Stop Yellin, directed by Kathy Najimy. The show consisted of autobiographical monologues and performances of songs from her CDs.
Wilhoite has a condition termed heterochromia; her right eye is blue-green and her left is brown. She and her husband David Harte have one son, Jimmy-Ray, born in 1995.