Chandramouli was born on November 15, 1898 in a village Moparru, Guntur district of Andhra Pradesh. He was educated in Scotland and acquired a post-graduate degree in agriculture. Upon his return to India he joined the freedom movement in 1926 relinquishing the government job. As a member of Indian National Congress he became president of Guntur district congress committee. He was imprisoned several times by the British government. He was elected as a member of the legislative assemblies of Madras province in 1937 and 1946, Andhra in 1955 and Andhra Pradesh in 1962.