Seto may refer to one of the following.
- Seto (瀬戸; lit: strait) is the name of several places in Japan
- Seto Inland Sea of Japan
- Sunrise Izumo/Sunrise Seto, a train in Japan
- Seto language (or Setu), a dialect spoken by the Setos, an ethnic and linguistic minority in south-eastern Estonia and north-western Russia
- Seto, a surname found most often in Japan
- Seto, a Japanese given name, almost always fictional
- Seto Kaiba, a main character from the Japanese manga and anime series, Yu-Gi-Oh!
- Seto Kamiki, a character from the Japanese Anime, Tenchi Muyo!
- Seto, a fictional character from the Squaresoft role-playing game Final Fantasy VII
- Seto no Hanayome, a manga and anime series