(Kyoto Encyclopedia of Genes and Genomes
) is a collection of online databases
dealing with genomes
, enzymatic pathways
, and biological chemicals. The PATHWAY database records networks of molecular interactions
in the cells, and variants of them specific to particular organisms.
The KEGG, the Kyoto
Encyclopedia of Genes and Genomes, was initiated by the Japanese human genome programme in 1995. According to the developers they consider KEGG to be a "computer representation" of the biological system. The KEGG database can be utilized for modeling and simulation, browsing and retrieval of data. It is a part of the systems biology approach.
KEGG maintains five main databases
- KEGG Atlas
- KEGG Pathway
- KEGG Genes
- KEGG Ligand
- KEGG BRITE
KEGG connects known information on molecular interaction networks
, such as pathways and complexes (this is the Pathway Database), information about genes and proteins
generated by genome projects (including the gene database) and information about biochemical compounds and reactions (including compound and reaction databases). These databases are different networks, known as the protein network, the gene universe and the chemical universe respectively. There are efforts in progress to add to the knowledge of KEGG, including information regarding ortholog
clusters in the KO (KEGG Orthology) database.
- RPAIR (Reactant pair alignments)
Comparative Toxicogenomics Database
integrates KEGG pathways with toxicogenomic and disease data