Junctional diversity

Junctional diversity

Junctional Diversity results from the improper joining of gene (V, D, and J) segments.

The inaccuracies in the joining of these genes is estimated to triple the diversity initally generated by these V(D)J recombinations.

Process

Junctional Diversity (as opposed to Combinatorial Diversity).

1. Nucleotides are removed by an exonuclease.

2. N-region nucleotides are added by Tdt (Terminal deoxyribonucleotidyl Transferase).

Result: Provides even greater diversity to Antibodies and T cell receptors.

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