Music

• JoJo (singer), American singer and actress
• JoJo (album), her 2004 debut album
• "Jojo", a single by Boz Scaggs from his 1980 album Middle Man
• Jojo, a character in the Beatles song "Get Back"
• Jojo Garza, American musician, member of Los Lonely Boys
• Joel "Jo-Jo" Hailey, American R&B singer
• K-Ci and JoJo, an American R&B duo featuring Hailey
• Jojo Mayer, Swiss drummer
• John "JoJo" Hermann, American musician, keyboardist for Widespread Panic
• Jo Jo Hoo Kim, Jamaican reggae record producer
• Jo Jo Laine, American singer, model, actress, and rock groupie
• JoJo, nickname for Jonathan Richman, American proto-punk singer and founder of The Modern Lovers
• Joseph "JoJo" Simmons, member of Team Blackout

Sports

• JoJo Starbuck, American figure skater
• Jojo Lastimosa, Filipino professional basketball player
• Jojo Townsell, American professional football player
• Jo Jo English, American professional basketball player
• Jo Jo White, American professional basketball player
• Jo-Jo Moore, American professional baseball player
• Jo-Jo Reyes, American professional baseball pitcher
• Jojo (Angola footballer), Angolan midfielder with Grupo Desportivo Sagrada Esperança
• Jojo (Mozambique footballer), Mozambiquan defender on the 1998 African Cup of Nations Team of the Tournament

Television

• Mojo Jojo, a simian character in the American animated TV show The Powerpuff Girls
• JoJo's Circus, an American children's TV show featuring the character JoJo Tickle
• Jojo (Digiturk channel), the children's and cartoon channel on Turkey's Digiturk
• Jojo the Kissing Bandit, a character in the Avatar: The Last Airbender trading card game

Other persons

• Jojo Chintoh, Canadian television journalist
• Jojo Masashige, Japanese samurai of the 16th and 17th centuries
• Jojo Moyes, British novelist
• JoJo Savard, Canadian self-proclaimed psychic
• Jo-Jo The Dog-Faced Boy, Fedor Jeftichew, Russian–American sideshow performer of the late 1800s
• Jejomar Binay, nicknamed JoJo, Filipino politician, mayor of Makati

Other uses

• Jojo CMS, an open source content management system
• Jo-Jo, Congo King, a fictional character in comic books published by Fox Feature Syndicate
• JoJo's Bizarre Adventure, a manga, anime, and video game in which every main character's name can be read as JoJo
• Jojo (comics), a comics series (and its title character) created by André Geerts, recipient of a 2003 Prix Saint-Michel
• Jojo, a 1988 novel by Roger Caron
• Jojos, an American regional name for potato wedges
• Jo Jo Dancer, the title character, played by Richard Pryor, in the film Jo Jo Dancer, Your Life Is Calling