He wrote on electronics and information theory, and developed jointly the concept of Pulse code modulation (PCM) with his Bell Labs colleagues Barney Oliver and Claude Shannon. He supervised the Bell Labs team which built the first transistor, and at the request of one of them, Walter Brattain, coined the term transistor.
Pierce's early work at Bell Labs was on vacuum tubes of all sorts. During World War II he discovered the work of Rudolf Kompfner in a British radar lab, where he had invented the traveling-wave tube; Pierce worked out the math for this broadband amplifier device, and wrote a book about it, after hiring Kompfner for Bell Labs. He later recounted that "Rudy Kompfner invented the traveling-wave tube, but I discovered it." According to Kompfner's book, the statement "Rudi invented the traveling-wave tube, and John discovered it" was due to Dr. Eugene G. Fubini, quoted in The New Yorker "Profile" on Pierce, September 21, 1963.
Pierce is widely credited for saying "Nature abhors a vacuum tube", but Pierce attributed that quip to Myron Glass
Others say that quip was "commonly heard at the Bell Laboratories prior to the invention of the transistor."
Other famous Pierce quips are "Artificial intelligence is real stupidity", "I thought of it the first time I saw it", and "After growing wildly for years, the field of computing appears to be reaching its infancy."
He did significant research into satellites, including an important leadership role (as vice President of Bell Laboratories for Research) in the development of the first commercial communications satellite, Telstar 1. In fact, although Arthur C. Clarke was the first to propose geostationary communications satellites, Pierce seems to have arrived at the idea independently and may have been the first to discuss unmanned communications satellites. See ECHO - America's First Communications Satellite (reprinted from SMEC Vintage Electrics Volume 2 #1) for some details on his original contributions.
After leaving Bell Laboratories, he joined Caltech as a professor of electrical engineering in 1970. Shortly thereafter, he also took the position of Chief Engineer at the Jet Propulsion Laboratory. In 1980 he retired from Caltech and moved to his final position at CCRMA.
He was prominent in the research of computer music, as Visiting Professor of Music, Emeritus at Stanford's CCRMA (along with John Chowning and Max Mathews).
Many of Pierce's technical books were written at a level intended to introduce a semi-technical audience to modern technical topics. Among them are Electrons, Waves, and Messages; An Introduction to Information Theory: Symbols, Signals, and Noise; Waves and Ear; Man's World of Sound; and Quantum Electronics.
Besides his technical books, Pierce wrote science fiction under the pseudonym J.J. Coupling. He seems to have been a firm believer in the connection between literary imagination and practical innovation. John Pierce also had an early interest in gliding and assisted in the development of the Long Beach Glider Club in Los Angeles, California, one of the earliest glider clubs in the United States.
In 1963, Pierce received the IEEE Edison Medal for "his pioneer work and leadership in satellite communications and for his stimulus and contributions to electron optics, travelling wave tube theory, and the control of noise in electron streams." In 1975, he received the IEEE Medal of Honor for "his pioneering concrete proposals and the realization of satellite communication experiments, and for contributions in theory and design of traveling wave tubes and in electron beam optics essential to this success."
Pierce had been a resident of Berkeley Heights, New Jersey, Pasadena, California, and later of Palo Alto, California.