Pathon was originally drafted 32nd overall in the second round of the 1998 NFL Draft by the Indianapolis Colts. He was also selected by the Montreal Alouettes in the second round (11th overall) of the 1997 Canadian College Draft, although he has not played a game in Canada to date. Pathon played 46 regular-season games for Indianapolis (1998-2001) as well as 45 games for the New Orleans Saints from 2002-2004. As a member of the 2003 Saints, he became best known for his role as the receiver who scored the touchdown on the famous River City Relay play. Prior to playing in the NFL, Pathon attended the University of Washington.
Pathon was a student of Carson Graham Secondary School in North Vancouver, British Columbia, Canada from 1987-1992 and attended Acadia University in Wolfville, Nova Scotia, Canada for one year (1993-1994) where he had 44 receptions and 868 receiving yards and was named AUS and CIAU Football Rookie of the Year,
Jerome Pathon is also mentioned in a recent Lil Wayne song titled 'Fly Out' from the album The Carter II. 'Say my name and die in the daytime, You catch my drift man you better be Pathon'. Referencing Pathon's play for Lil Wayne's New Orlean Saints.