• Billy Jayne, an American television and film actor
• Caroline Furness Jayne, an American ethnologist
• Francis Jayne, a British bishop and academic
• Keith Jayne, a British television actor
• Robert Jayne, an American actor
• William Jayne, an American statesman and governor during the American Civil War

It is also a Christian name, as a variety to Jane.

See also

• Jayne Atkinson, an American actress
• Jayne Cobb, a character from the television series Firefly
• Jayne Grayson, a character from the television series Holby City
• Jaynes
• Jane
• Jain