Roger Waters, former member of Pink Floyd, cites "Isolation" as one of his favourite songs of all time.
The song was covered by Snow Patrol in 2005, for Make Some Noise, Amnesty International, which was later released on the 2007 John Lennon tribute album, Instant Karma: The Amnesty International Campaign to Save Darfur.
Maxïmo Park did a 90-second cover version as a B-side, which was also released on the 2006 compilation album Missing Songs.
Ann Wilson, lead singer of Heart, recorded a cover version of this song for her 2007 solo release Hope & Glory.
Britt Daniel from Spoon has also performed the song live when playing solo.
Harry Nilsson, an American singer-songwriter, covered the song on his 1971 album Ariel Pandemonium Ballet.
Therapy?, a Northern Irish rock band, covered the song and released it as a single.