Ishtar was above all associated with sexuality: her cult involved sacred prostitution; her holy city Erech was called the "town of the sacred courtesans"; and she herself was the "courtesan of the gods". Ishtar had many lovers; however, as Guirand notes,
The gatekeeper lets Ishtar into the underworld, opening one gate at a time. At each gate, Ishtar has to shed one article of clothing. When she finally passes the seventh gate, she is naked. In rage, Ishtar throws herself at Ereshkigal, but Ereshkigal orders her servant Namtar to imprison Ishtar and unleash sixty diseases against her.
After Ishtar descends to the underworld, all sexual activity ceases on earth. The god Papsukal reports the situation to Ea, the king of the gods. Ea creates a eunuch called Asu-shu-namir and sends him to Ereshkigal, telling him to invoke "the name of the great gods" against her and to ask for the bag containing the waters of life. Ereshkigal is enraged when she hears Asu-shu-namir's demand, but she has to give him the water of life. Asu-shu-namir sprinkles Ishtar with this water, reviving her. Then Ishtar passes back through the seven gates, getting one article of clothing back at each gate, and is fully clothed as she exits the last gate.
Here there is a break in the text of the myth. The text resumes with the following lines: Formerly, scholars believed that the myth of Ishtar's descent took place after the death of Ishtar's lover, Tammuz: they thought Ishtar had gone to the underworld to rescue Tammuz. However, the discovery of a corresponding myth about Inanna, the Sumerian counterpart of Ishtar, has thrown some light on the myth of Ishtar's descent, including its somewhat enigmatic ending lines. According to the Inanna myth, Inanna can only return from the underworld if she sends someone back in her place. Demons go with her to make sure she sends someone back. However, each time Inanna runs into someone, she finds him to be a friend and lets him go free. When she finally reaches her home, she finds her husband Dumuzi (Babylonian Tammuz) seated on his throne, not mourning her at all. In anger, Inanna has the demons take Dumuzi back to the underworld as her replacement. Dumuzi's sister Geshtinanna is grief-stricken and volunteers to spend half the year in the underworld, during which time Dumuzi can go free. The Ishtar myth presumably has a comparable ending, Belili being the Bablyonian equivalent of Geshtinanna.
While Gilgamesh and Enkidu are resting, Ishtar stands upon the walls of the city (which is Uruk) and curses Gilgamesh. Enkidu tears off the Bull's right thigh and throws it in Ishtar's face, saying, "If I could lay my hands on you, it is this I should do to you, and lash your entrails to your side." Then Ishtar called together "her people, the dancing and singing girls, the prostitutes of the temple, the courtesans," and had them mourn for the Bull of Heaven.