Recent archaeological research results (and published works of oral history experts, anthropologists and archaeologists of the Arizona State University, USA and the University of Ibadan, Nigeria); of the region's contemporary and later settlements suggest that Ìsẹ̀dó was founded between the 10th and the 12th centuries by Ọ̀bà refugees fleeing from internal dissension in their Òbà kingdom as well as the cyclic conflicts of their Ọ̀bà kingdom with the neighbouring kingdoms, perhaps including the Nupe to the north.
While it has maintained the royal title of Oba'lúmò, the kingdom of Ìsẹ̀dó has in modern times been virtually engulfed by the present-day Ila Ọrangun such that the old Isedo township now lies (at ), in the southeast quadrant of Ila Orangun. In Oke-Ila, the oratures of the Ọbaálá clan refer to their origin from Ìsèdó, indicating that they are actually a segment of the Ìsẹ̀dó royalty which emigrated several centuries ago to an alliance with the new kingdom of Oke-Ila Ọrangun after [and possibly before] the latter's departure from Ila-Yara. The Ọba'lumọ-led emigrants from Ìsẹ̀dó collaborated with the reigning Ọ̀ràngún's group during the latter's refuge-taking sorties out of "Igbohun" and possibly also during their original emigration journey out of Ila-Yara.
In this quasi-consolidation arrangement with the new Oke-Ila Orangun state, the Ìsẹ̀dó immigrants retained their royal title of Ọba'lúmọ̀, and subsequently were accorded a new recognition, awarding their clan the title of Ọbaálá ("mighty king" or "senior king"), a title next in rank to the Ọ̀ràngún of Oke-Ila the paramount king. The Ọbaálá is also designated as the automatic regent upon the demise of any reigning Ọ̀ràngún.
Other examples of Igbomina and non-Igbomina towns (in Kwara and Ọṣun states of Nigeria) with large concentrations of Ọ̀bà people, now commonly called 'The Ọ̀bà Diaspora' , include the following: Oke-Ila Ọrangun, Ila Ọrangun, Ọra-Igbomina, Ipoti-Ekiti, Isanlu-Isin, Oke-Onigbin, Omu-Aran, Rorẹ, Ọyan, Inisha, Ipee, Oke-Ode, Babanla, Ajasẹ-Ipo, Omupo, Esiẹ, Oro, Ijomu-Oro, Iddo-Oro, Idofin, Ado-Eku, Oreke, Sanmora, and Pamo.
The Ìsẹ̀dó clans appear to be the earliest surviving [but perhaps not the only] group in the 'The Ọ̀bà Diaspora' that purposefully set out and founded a surviving kingdom ruled by the king Ọba'lumọ. Subsequent Ọ̀bà-derivative kingdoms and diaporas appear to have resulted solely from refugee flights from wars and slave raids.