Boethius' translation of the work, in Latin, became a standard medieval textbook in European schools and universities, setting the stage for medieval philosophical-theological developments of logic and the problem of universals. Many writers, such as Boethius himself, Averroes, Abelard, Scotus, wrote commentaries on the book. Other writers such as Ockham incorporated them into their textbooks on logic.
The Introduction was translated into Arabic by Ibn al-Muqaffa‘ from a Syriac version. With the Arabicized name Isāghūjī it long remained the standard introductory logic text in the Muslim world and influenced the study of theology, philosophy, grammar, and jurisprudence. Besides the adaptations and epitomes of this work, many independent works on logic by Muslim philosophers have been entitled Isāghūjī. Porphyry's discussion of accident sparked a long-running debate on the application of accident and essence.
The predicables (Lat. praedicabilis, that which may be stated or affirmed, sometimes called quinque voces or five words) is, in scholastic logic, a term applied to a classification of the possible relations in which a predicate may stand to its subject. The list given by the schoolmen and generally adopted by modern logicians is based on the original fivefold classification given by Aristotle (Topics, a iv. 101 b 17-25): definition (horos), genus (genos), differentia (diaphora), property (idion), accident (sumbebekos).
The scholastic classification, obtained from Boëthius's version the Isagoge, modified Aristotle's by substituting species (eidos) for definition.
In medieval textbooks, the all-important Arbor porphyriana ("Porphyrian Tree") illustrates his logical classification of substance. To this day, taxonomy benefits from concepts in Porphyry's Tree, in classifying living organisms: see cladistics.
The work is celebrated for prompting the medieval debate over the status of universals. Porphyry writes
Though he did not mention the problem further, his formulation constitutes the most influential part of his work, since it was these questions that formed the basis of medieval debates about the status of universals. Do universals exist in the mind, or in reality? If in reality, are they physical things, or not? If physical, do they have a separate existence from physical bodies, or are they part of them?