Noted for her seductive brown eyes and coquettish personality, Irène Bordoni is probably best remembered from musical theatre as the star of the 1928 Cole Porter musical Paris that featured the song "Let's Do It (Let's Fall In Love)" which became Porter's first big success. Bordoni would record and sing many times live and on radio another Cole Porter song, "Let's Misbehave" with Irving Aaronson and His Commanders dance band. The song has been included on the soundtrack of five motion pictures including Everything You Always Wanted To Know About Sex (But Were Afraid to Ask) (1972), Pennies from Heaven (1981) and Bullets Over Broadway (1994).
In 1929 her Broadway play Paris was adapted to a talkie, also called Paris, for which she reprised her starring role. The film used the Vitaphone sound-on-disc sound system and was shot in early Technicolor. That year Bordoni also performed a song for the Warner Brothers film The Show of Shows produced by Darryl F. Zanuck. In 1932 Max Fleischer featured her in his follow-the-bouncing-ball Screen Song cartoon 'Just A Gigolo'
Her status as a major star of the American stage was such that in his song "You're The Top", Cole Porter included the reference "You’re the eyes of Irene Bordoni". During the 1930s, she continued to perform on stage and starred in another Warner Brothers musical comedy film. In 1940, Bordoni was part of another major Broadway success with the Irving Berlin musical Louisiana Purchase and again reprised her role in the Paramount Pictures film Louisiana Purchase (1941) with Bob Hope. She had another success in the role of "Bloody Mary" in the 1951 national tour of the musical South Pacific.