As other example, an intrathecal injection (often simply called "intrathecal") is an injection into the spinal canal (intrathecal space surrounding the spinal cord), as in a spinal anaesthesia or in chemotherapy or pain management applications. This route is also used for some infections, particularly post-neurosurgical. The drug needs to be given this way to avoid the blood brain barrier. The same drug given orally must enter the blood stream and has a much harder time reaching the brain; by the time it does, most of the drug has been absorbed by the body's system and is excreted. Drugs given intrathecally often have to be made up specially by a pharmacist or technician because they cannot contain any preservative or other potentially harmful inactive ingredients that are sometimes found in standard injectable drug preparations.
Often reserved for spastic cerebral palsy, intrathecally-administered baclofen is done through a intrathecal pump implanted just below the skin of the stomach with a tube connected directly to the base of the spine, where it bathes the appropriate nerves using a dose about one thousand times smaller than that required by orally-administered baclofen. Intrathecal baclofen also carries none of the side effects, such as sleepiness, that typically occur with oral baclofen. It is the preferred route for long-term management of spasticity in people with CP for whom other procedures, such as rhizotomy or orthopedic surgery, are inappropriate.
Researchers Submit Patent Application, "Method to Inhibit Neuropathic Pain by Intrathecal Injection of Protein Phosphatases", for Approval
Jan 10, 2013; By a News Reporter-Staff News Editor at Politics & Government Week -- From Washington, D.C., VerticalNews journalists report that...
Wipo Publishes Patent of Wisconsin Alumni Research Foundation, Miletic Vjekoslav, Miletic Gordana for "Method to Inhibit Neuropathic Pain by Intrathecal Injection of Protein Phosphatases" (American Inventors)
Jan 06, 2013; GENEVA, Jan. 6 -- Publication No. WO/2012/177497 was published on Dec. 27, 2012.Title of the invention: "METHOD TO INHIBIT...