As of June 25, 2007, the Veterans' Glass City Skyway was opened, replacing the Craig Memorial Bridge, thus taking I-280 off the short list of drawbridges in the Interstate highway system. After the Glass City Skyway opened, the Craig Bridge was rehabilitated and now carries State Route 65.
| # | Destinations | Notes |
|---|---|---|
| 1A | , Chicago | |
| 1B | Hanley Road, Latcha Road | |
| 2 | ||
| 4 | Walbridge | |
| 6 | ||
| 7 | ||
| 8 | Starr Avenue | southbound exit and northbound entrance |
| 9 | ||
| 11 | ||
| 12 | Manhattan Boulevard | |
| - to I-475 | northbound exit and southbound entrance | |
| - Detroit | northbound exit and southbound entrance |