Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, signal transduction

In 2008, ILK was found to localize to the centrosome and regulate mitotic spindle organization.

References

Further reading

• Fielding A, Dobreva I, McDonald PC, et al. (2008). "Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization.". J. Cell Biol. 180 (4): 681–9.