ATP + 1D-myo-inositol 1,4,5-trisphosphate $rightleftharpoons$ ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 1,4,5-trisphosphate, whereas its two products are ADP and 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase. Other names in common use include 1D-myo-inositol-trisphosphate 3-kinase, and Ins(1,4,5)P3 3-kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, calcium signaling pathway, and phosphatidylinositol signaling system. This enzyme has at least one effector, Calcium.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

References

• Hansen CA, Mah S, Williamson JR "Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver". J. Biol. Chem. 261 8100–3.
• Irvine RF, Letcher AJ, Heslop JP, Berridge MJ "The inositol tris/tetrakisphosphate pathway — demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues". Nature. 320 631–4.
• Irvine RF, Schell MJ "Back in the water: the return of the inositol phosphates". Nat. Rev. Mol. Cell. Biol. 2 327–38.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes