The company published many adaptations and tie-in series of existing media properties, such as Anne Rice's novels Interview with the Vampire, The Vampire Lestat, and Queen of the Damned. It also published Piers Anthony's Incarnations of Immortality: On a Pale Horse; the TV series Dark Shadows, Quantum Leap, Beauty and the Beast and Lost in Space; and the movie series Child's Play, A Nightmare on Elm Street among others.
Innovation's original series included Angel Heat; Campiti's The Bodacious Adventures of Biff Thundersaur; Dangerous Secrets; Dream Angel; The Experimentals; writer Al Rio's Exposure; Galaxy Girl; Greylore; writer Kevin Juaire's Hero Alliance; Legends of the Stargrazers; and writer Mike Barr's The Maze Agency (continuing a series originally published by Comico).
Innovation was one the first companies to delve heavily into recruiting talents from Brazil, starting the American careers of Mike Deodato and Joe Bennett, among others. The 1992 Russ Manning "Best Newcomer" Award-winner, Mike Okamoto, broke into comic books illustrating The Maze Agency #15 (Aug. 1990) and Hero Alliance #11-12 (Nov.-Dec. 1990).
In 1994, Innovation closed, a year after Campiti left to launch Glasshouse Graphics, a studio/agency for illustrators, writers, painters, and digital designers.