SR 67 is a two-lane highway from Vincennes to near Martinsville, where it becomes a four-lane limited-access highway. SR 67 overlaps U.S. Highway 231 from three miles southwest of Worthington, Indiana, to six miles north of Spencer, a distance of approximately 30 miles.
Once SR 67 reaches Indianapolis, as Kentucky Avenue, it overlaps Interstate 465 around the south and east sides of the city until Exit 42, where SR 67 and U.S. Highway 36 depart the city to the northeast as Pendleton Pike. U.S. Highway 36 splits off from State Road 67 in Pendleton and proceeds east.
Northeast of Muncie, SR 67 wraps up its diagonal run in the same manner as it began: as a rural, two-lane highway. Portions of the route overlap others.