The play deals with Jelinek's usual play on sexual power-politics by focusing attention on a couple and what happens to the dynamics of their relationship when change occurs. The change, in this case, is when Carmilla, a housewife, becomes a vampire through her friend Emily. This only occurs after the birth of her daughter. She then leaves her husband, Dr. Benno Hundekoffer, and establishes a lesbian relationship with Emily. Like the rest of Jelinek's body of work, Krankheit offers a vitriolic and satirical view of the falsity and susceptibility concerning relationships.