In medicine:

• Intensive care unit, a specialized facility in a hospital that provides intensive care medicine

In film

• I.C.U., the 2008 Australian thriller starring Christian Radford

In universities:

• Information and Communications University, a research university located in Daejeon, South Korea
• International Christian University, a private university located in Mitaka, Tokyo, Japan
• International Christian University - Kyiv, a private university located in Kyiv, Ukraine

In computers and electronics:

• International Components for Unicode, software libraries supporting internationalization
• Instruction cache unit, a CPU cache for caching processor instructions
• Interface control unit, a control unit between electronic circuits
• Interactive Chart Utility, a feature of IBM's GDDM Product

In politics:

• International Clearing Union, a non-existent currency regulatory institution proposed in 1944
• International Communist Union, an international grouping of Trotskyist political parties
• Islamic Courts Union, an armed group of Sharia courts in Somalia

In other fields:

• Intersection Capacity Utilization, which measures the capacity of a roadway intersection
• Imperial College Union, the students union of Imperial College London
• International Cycling Union, known by the French name of Union Cycliste Internationale
• Irish Cricket Union
• InCheon United