Their first mission was to ambush Cable and X-Force at their base in the Adirondacks. They attacked just as X-Force was preparing to vacate the base, as its secrecy had already been compromised by Tolliver and Deadpool. The base had been rigged to self-destruct, and it did just that during Weapon P.R.I.M.E.'s fight to capture Cable. Cable escaped, and they tried to capture the members of X-Force instead, also failing at that. Instead, X-Force ended up recruiting Rictor and escaping with the IPAC. After this Grizzly left the team and Bridge and Kane resumed their normal duties.
The new and final line-up consisted of Tygerstryke, Yeti, Double Trouble, and Killjoy (aka Killspree). They were next seen in X-Force #22-23 attempting to stop former Six Pack members Grizzly, Domino, and Hammer from stealing files on Cable from Department K. The infiltrators downloaded the entire chunk of encrypted data, and narrowly escaped the team by going through the ceiling and ductwork.
After the demise of Alpha Flight, Weapon P.R.I.M.E. was sent after Northstar (Northstar #1-4). They tracked him to a villa on the north coast of Ibiza, but are given the slip and accidentally kill the wrong man outside. They ransack the house, annoyed by the fact that his sheets were even still warm. They next track Northstar to Zuyevo, Russia; and find him being attacked by circus performers under mind-control by Arcade. Northstar immediately surrenders to the team, at which point the team itself comes under attack by the circus performers! Killspree thinks they're part of a trap set by Northstar, but Northstar convinces Tygerstryke of the mind-control, and together they find and destroy Arcade's device. Northstar then escapes (with the help of Guardian), and is next caught up with by Weapon P.R.I.M.E. at the top of the New Orleans World Trade Center. Tygerstryke sees him and radios the rest of the team, but is attacked by Guardian who tells him they'll all have to go through her to get to Northstar. Tygerstryke grimices and admits it wouldn't seem worth it, as the action in Russia made him think well of Northstar. Guardian tells him to get used to bending the rules sometimes, as that's what it will take to replace Alpha Flight