Hydroxyzine/reference table

• Antihistamine -- Competitive antagonist of histamine, H₁ histamine receptor and antiemetic, anxiolytic.

• Alcohol withdrawal anxiety
• Anxiety manifested by organic disease states
• Nausea or nauseating conditions

• Syrup
• Oral Suspension
• Tablet form
• Capsule form

• Oral administration onset: 15-30 minutes
• Suppression of wheal & flare response to allergenic skin extract: 4 days.

• Pruritus: 6-42 μg/L (14-102 nmol/L) (Suppresses pruritus in children)

Peak serum level

• Healthy adults -- 73 ± 11 μg/L occurs 2 ± 0.4 hr after a 0.7 mg/kg dose
• Primary biliary cirrhosis'' -- 117 ± 61 μg/L at 2.3 ± 0.7 hr after 44mg mean dose

V_d

• Children -- 19 ±9 L/kg
• Healthy adults -- 16 ± 3 L/kg
• Elderly -- 23 ± 6 L/kg
• Primary biliary cirrhosis -- 23 ±13 L/kg

Cl

• Children -- 1.9 L/hr/kg
• Healthy young/elderly adults -- 0.6 ± 0.2 L/hr/kg
• Primary biliary cirrhosis -- 0.5 ±0.4 L/hr/kg

t_½

• Children -- 7hr (increases with age)
• Healthy adults -- 20 ± 4 hr
• Elderly -- 29 ± 10 hr
• Primary biliary cirrhosis -- 37 ±13 hr