Hydroxypyruvate reductase

D-glycerate + NAD(P)+ $rightleftharpoons$ hydroxypyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-glycerate, NAD⁺, and NADP⁺, whereas its 4 products are hydroxypyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glycerate:NADP+ 2-oxidoreductase. Other names in common use include beta-hydroxypyruvate reductase, NADH:hydroxypyruvate reductase, and D-glycerate dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.

References

• Kleczkowski LA and Edwards GE "Identification of hydroxypyruvate and glyoxylate reductases in maize leaves". Plant Physiol. 91 278–286.
• Kleczkowski LA, Randall DD "Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases". Biochem. J. 250 145–52.
• Kohn LD, Jakoby WB "Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase)". J. Biol. Chem. 243 2494–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes