Hydroxymethylglutaryl-CoA hydrolase

(S)-3-hydroxy-3-methylglutaryl-CoA + H₂O $rightleftharpoons$ CoA + 3-hydroxy-3-methylglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxy-3-methylglutaryl-CoA and H₂O, whereas its two products are CoA and 3-hydroxy-3-methylglutarate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase. Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.

References

• DEKKER EE, SCHLESINGER MJ, COON MJ "beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase". J. Biol. Chem. 233 434–8.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes