Hydroxymandelonitrile lyase

(S)-4-hydroxymandelonitrile $rightleftharpoons$ cyanide + 4-hydroxybenzaldehyde

Hence, this enzyme has one substrate, (S)-4-hydroxymandelonitrile, and two products, cyanide and 4-hydroxybenzaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• AJ "Population pharmacokinetics of liposomal amphotericin B in pediatric patients with malignant diseases". Antimicrob. Agents. Chemother. 50 935–42.
• Seely MK, Criddle RS, Conn EE "The metabolism of aromatic compounds in higher plants. 8. On the requirement of hydroxynitrile lyase for flavin". J. Biol. Chem. 241 4457–62.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes