, a hydrogen dehydrogenase (NADP+)
is an enzyme
the chemical reaction
- H2 + NADP+ H+ + NADPH
Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
- de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z "The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity". Biochem. Biophys. Res. Commun. 248 591–6.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes