Hydrogen dehydrogenase (NADP )

Hydrogen dehydrogenase (NADP+)

In enzymology, a hydrogen dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

H2 + NADP+ rightleftharpoons H+ + NADPH

Thus, the two substrates of this enzyme are H2 and NADP+, whereas its two products are H+ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on hydrogen as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen:NADP+ oxidoreductase. Other names in common use include NADP+-linked hydrogenase, NADP+-reducing hydrogenase, hydrogen dehydrogenase (NADP+), and simply hydrogenase (which is ambiguous).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .


  • de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z "The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity". Biochem. Biophys. Res. Commun. 248 591–6.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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