O-phosphoserine sulfhydrylase

O-phospho-L-serine + hydrogen sulfide $rightleftharpoons$ L-cysteine + phosphate

Thus, the two substrates of this enzyme are O-phospho-L-serine and hydrogen sulfide, whereas its two products are L-cysteine and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase. This enzyme is also called O-phosphoserine(thiol)-lyase. This enzyme participates in cysteine metabolism and sulfur metabolism.

References

• Mino K, Ishikawa K "A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1". FEBS. Lett. 551 133–8.
• Mino K, Ishikawa K "Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1". J. Bacteriol. 185 2277–84.
• Mino K, Oda Y, Ataka M, Ishikawa K "Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1". Acta. Crystallogr. D. Biol. Crystallogr. 59 338–40.

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